PAK1-dependent mechanotransduction enables myofibroblast nuclear adaptation and chromatin organization during fibrosis
Summary: Myofibroblasts are responsible for scarring during fibrosis.The scar propagates mechanical signals inducing a radical transformation in myofibroblast cell state and increasing profibrotic phenotype.Here, we show mechanical stress from progressive scarring induces nuclear softening and de-repression of heterochromatin.The parallel loss of H